Research
The Colon and Rectal Surgery department focuses on innovative approaches to the treatment of colon and rectal cancers, linking high-quality patient care, preservation of life and translational research.
Our research spans all aspects and stages of colorectal cancer, from screening and prevention to multi-disciplinary approaches for treating advanced cancers.
Research Programs
Minimally invasive surgery and enhanced recovery
The Colon and Rectal Surgery department is a world leader on innovative treatments of cancer using minimally invasive robotic and laparoscopic techniques, including for complex cancers. We utilize an Enhanced Surgical Recovery program that combines advanced minimally invasive surgery, evidence-based peri-operative care and innovations in tele-health to maximize each patient's healing. This allows our patients to proceed to the next step of treatment faster and healthier.
Topics our group is studying:
- TeleRecovery to facilitate short-stay enhanced recovery after minimally-invasive surgery for colorectal cancer
- Tele-health for patients with an ostomy
- Short and long-term clinical outcomes after robotic surgery
- Advanced minimally invasive robotic surgery for complex cancers
Advanced techniques and multi-disciplinary treatment for advanced tumors
Our group has internationally recognized expertise in the evaluation and treatment of locally advanced and recurrent cancers. Our faculty are thought leaders in advanced techniques necessary to perform high-quality surgery for complex pelvic tumors. We partner with experts across MD Anderson to ensure a thoughtful approach to difficult-to-treat tumors that will provide the best outcomes for our patients.
Topics our group is studying:
- Role of pelvic exenteration for curative management of locally advanced and recurrent rectal cancer
- Multi-disciplinary management for lateral pelvic lymph node metastasis from rectal cancer
- Quality standards for colon and rectal cancer surgery
- Impact of primary tumor resection in stage IV colorectal cancer
Organ preservation and quality of life
Our multidisciplinary experts tailor cancer therapy for each patient using advanced chemotherapy, radiotherapy and immunotherapy before surgery. The goal of such comprehensive cancer care is not only improving outcomes after surgery but maximizing the chance to preserve function and improve quality of life after surgery.
Topics our group is studying:
- Short-course and total neoadjuvant therapy for rectal cancer
- Avoiding the need for surgery (watch and wait) for rectal cancer
- Advanced surgical techniques to preserve sphincter function
- Cancer survivorship and quality of life after colorectal cancer treatment
Hereditary and young-onset colorectal cancer
The Colon and Rectal Surgery department at MD Anderson has extensive experience in the treatment of hereditary colorectal cancers and hereditary syndromes that include colorectal cancer. Young patients with colorectal cancer need specialized cancer care. This includes surveillance of possible future secondary cancers and screening of family members. We partner with the Colorectal Center Genetics Clinic to provide surveillance, prevention and genetic risk evaluation for patients with inherited or early-onset cancer.
Topics our group is studying:
- Practice guidelines for young adult-onset colorectal cancer
- Genetic factors associated with young-onset colorectal cancer
- Screening for colorectal cancer
Peritoneal carcinomatosis
The Colorectal Center at MD Anderson combines the expertise of medical oncologists, surgeons and translational researchers to study and treat peritoneal carcinomatosis (metastases within the abdominal cavity) from colorectal cancer. Our institution cares for patients with a wide spectrum of disease and provides individualized treatment plans tailored to each person's unique biology and situation.
Topics our group is studying:
- Genetics-guided treatment of colorectal cancer
- Genomics of metastatic colorectal cancer and carcinomatosis
- Outcomes following cytoreductive surgery for colorectal carcinomatosis
Translational Research
Research that translates into improved outcomes for cancer is the heart of M.D. Anderson. Our clinician-scientists work across the spectrum of
disciplines to develop innovative approaches to treat cancer from the earliest to the most advanced stages. We collaborate closely with international other leaders in the study of the basic mechanisms of cancer development and novel treatments for colorectal cancer. Translational research in the department is informed and informed by the daily clinical care of our patients to optimize outcomes now and in the future for our patients.
Topics our group is studying:
- Using next-generation sequencing and circulating tumor DNA to guide treatment decisions
- The interaction of the immune system and colorectal cancer
- The biology of colorectal cancer growth and metastatic spread
-The role of the gut and tumoral microbiome in effecting cancer development, progression, and response to therapies in local and metastatic colorectal cancer
Clinical Trials
2023-0880
A phase II trial utilizing metronidazole to optimize the microbiome of rectal adenocarcinoma undergoing neoadjuvant therapy
2023-0549
Prehabpal: A digital tool to help frail elders prepare for surgery
NIH link: NCT05520866
2023-0214
A Prospective Feasibility Study Using ctDNA to Tailor Neoadjuvant Chemotherapy for Patients with Colorectal or Appendiceal Adenocarcinoma
NIH link: NCT05947838
2016-0549
Organ Preservation with AcTive Surveillance after ChemOradiation in Rectal CaNcer (OPTION)
NIH link: NCT03594630
2020-0602
SWOG S1820: A Randomized Trial of the Altering Intake, Managing Symptoms Intervention for Bowel Dysfunction in Rectal Cancer Survivors Compared to a Healthy Living Education Control: A Feasibility and Preliminary Efficacy Study (AIMS-RC)
NIH link: NCT04205955
ALLIANCE A231601CD
IMPROVING SURGICAL CARE AND OUTCOMES IN OLDER CANCER PATIENTS THROUGH IMPLEMENTATION OF AN EFFICIENT PRE-SURGICAL TOOLKIT (OPTI-SURG)
NIH link: NCT03857620
ALLIANCE A021502
Randomized Trial of Standard Chemotherapy Alone or Combined with Atezolizumab as Adjuvant Therapy for Patients with Stage III Colon Cancer and Deficient DNA Mismatch Repair
NIH link: NCT02912559
PA14-0259
Molecular Analysis of Young-Onset Colorectal Cancer
PA14-0935
PCORI Provider Survey on Treatment Eligibility
2013-0631
Prospective Evaluation of Quality of Life and Utilities Following Surgical Treatment of Rectal Cancer.
NIH link: NCT02107105
2013-0595
Quality of Life in Rectal Cancer Patients with Lynch Syndrome
PA13-0547
Facilitated Social Network for Rectal Cancer Survivors
NCCTG N1048
NCCTG N1048: A Phase II/III trial of Neoadjuvant FOLFOX, with Selective Use of Combined Modality Chemoradiation versus Preoperative Combined Modality Chemoradiation for Locally Advanced Rectal Cancer Patients Undergoing Low Anterior Resection with Total M
NIH link: NCT01515787
PA11-0566
Young-onset microsatellite-stable colorectal cancer
PA11-0567
Molecular basis for variations in hereditary colorectal cancer syndromes
NIH link: NCT02863172
2010-0796
Long-Term Survivorship and Quality of Healthcare Among Adults with Colorectal Cancer
2007-0322
A Pilot Study for Prospective Discovery of Possible Relationship Between Quality of Life, Treatment Modalities, and Patient Treatment/Outcome Expectations in Patients Undergoing Treatment for Locally Recurrent Rectal Adenocarcinoma
ECOG5202
Randomized Ph III Study Comparing 5-FU, Leucovorin & Oxaliplatin vs 5-FU, Leucovorin, Oxaliplatin & Bevacizumab in Patients w/ Stage II Colon Cancer at High Risk for Recurrence to Determine Prospectively the Prognostic Value of Molecular Markers
NIH link: NCT00217737
RCR06-0400
Correlation between methods of detection of patients with hereditary nonpolyposis colorectal cancer (HNPCC)
LAB04-0962
Molecular determinants of response to preoperative therapy in patients with locally advanced colorectal cancer
NIH link: NCT02877056
Publications
2024
Para-aortic Lymph Node Dissection for Colorectal Cancer: Predicting Pathologic Lymph Node Positivity and Optimizing Outcomes. Neal Bhutiani, Kentaro Ochiai, Muhammad O. Awiwi, Miguel A. Rodriguez-Bigas, Abhineet Uppal, Oliver Peacock, Craig Messick, Michael Geoffrey White, John M. Skibber, Brian K. Bednarski, Y. Nancy You, George J Chang, Harmeet Kaur, Tsuyoshi Konishi. Annals of surgical oncology. Sep 2024 31(9) 5962-5970. doi: 10.1245/s10434-024-15539-8. PMID: 38836917. View here
Anatomic Basis of Rectal Cancer Staging: Clarifying Controversies and Misconceptions. Harmeet Kaur, Helena Gabriel, Muhammad O. Awiwi, Ekta Maheshwari, Camila Lopes Vendrami, Tsuyoshi Konishi, Melissa W. Taggart, Michael Magnetta, Linda C. Kelahan, Sonia Lee. Radiographics. Jul 2024 44(7) e230203. doi: 10.1148/rg.230203. PMID: 38900679. View here
Leveraging Nursing Assessment for Early Identification of Post Operative Gastrointestinal Dysfunction (POGD) in Patients Undergoing Colorectal Surgery. Tessy Siby, Alice Shajimon, Daniel Mullen, Shahnaz Gillani, Jeffrey R. Ong, Nikki E. Dinkins, Brittany Kruse, Carla Patel, Craig Messick, Nicole Gourmelon, Mary R. Butler, Vijaya Gottumukkala. Current Oncology. Jul 2024 31(7) 3752-3757. doi: 10.3390/curroncol31070276. PMID: 39057148. View here
Improving Surgical Care and Outcomes in Older Cancer Patients Through implementation of a Pre-Surgical Toolkit (OPTI-Surg) - Final Results of a Phase III Cluster Randomized Trial (Alliance A231601CD). OPTI-Surg Investigators, George J. Chang, Heather J. Gunn, Anne K. Barber, Lisa M. Lowenstein, Daniel Dohan, Jeanette Broering, Travis Dockter, Angelina D. Tan, Amylou Dueck, Selina Chow, Heather Neuman, Emily Finlayson. Annals of surgery. Oct 2024 280(4) 623-632. doi: 10.1097/SLA.0000000000006458. PMID: 39069901. View here
The Learning Curve for Robotic Lateral Pelvic Lymph Node Dissection for Rectal Cancer: A View from the West. Annamaria Agnes, Oliver Peacock, Naveen Manisundaram, Youngwan Kim, Nir Stanietzky, Raghunandan Vikram, Brian K. Bednarski, Y. Nancy You, Tsuyoshi Konishi, George J. Chang. Diseases of the colon and rectum. Oct 2024 67(10) 1281-1290. doi: 10.1097/DCR.0000000000003424. PMID: 38959454. View here
Early Postoperative Prediction of Complications and Readmission after Colorectal Cancer Surgery Using an Artificial Neural Network. Annamaria Agnes, Sa Nguyen, Tsuyoshi Konishi, Oliver Peacock, Brian K. Bednarski, Nancy You, Craig Messick, Matthew Tillman, John Skibber, George J. Chang, Abhineet Uppal. Diseases of the colon and rectum. Oct 2024 67(10) 1341-1352. doi: 10.1097/DCR.0000000000003253. View here
Defining the subset of mutations in polymerase epsilon (POLE) associated with loss-of-proofreading (LOP) functionality. G. Maddalena, F. A. Zeineddine, S. Rivero-Hinojosa, V. N. Aushev, S. Chowdhury, M. A. Zeineddine, A. M. Yousef, T. A. Yap, A. C. EINaggar, M. C. Liu, M. White, M. J. Overman, S. Kopetz, J. P. Shen. Annals of Oncology. Jul 2024 35(7) 678- 680. doi: 10.1016/j.annonc.2024.04.009. PMID: 38734075. View here
Incomplete Cytoreduction and Need for Major Hepatectomy Predict Shorter Survival in Patients Undergoing Combined Cytoreductive Surgery and Hepatectomy for Metastatic Colorectal Cancer. Reed I. Ayabe, Karen Beaty, Timothy E. Newhook, Hop S.Tran Cao, Ching-Wei David Tzeng, Beth A. Helmink, Abhineet Uppal, Jean Nicolas Vauthey, Keith F. Fournier, Michael Geoffrey White. Annals of surgical oncology. Oct 2024 31(10) 6366-6368. doi: 10.1245/s10434-024-15694-y. View here
SWOG S1820: A pilot randomized trial of the Altering Intake, Managing Bowel Symptoms Intervention in Survivors of Rectal Cancer. Virginia Sun, Katherine A. Guthrie, Tracy E. Crane, Kathryn B. Arnold, Sarah Colby, Sarah G. Freylersythe, Christa Braun-Inglis, Roxanne Topacio, Craig A. Messick, Joseph C. Carmichael, Andrew A. Muskovitz, Mo Nashawaty. Cancer. Jul 2024 130(13) 2384-2394. doi: 10.1002/cncr.35264. PMID: 38386696. View here
Colon Cancer, Version 3.2024. Al B. Benson, Alan P. Venook, Mohamed Adam, George Chang, Yi Jen Chen, Kristen K. Ciombor, Stacey A. Cohen, Harry S. Cooper, Dustin Deming, Ignacio Garrido-Laguna, Jean L. Grem, Paul Haste, J. Randolph Hecht, Hoffe. JNCCN Journal of the National Comprehensive Cancer Network. Jun 2024 22(2d) e240029. doi: 10.6004/jnccn.2024.0029. PMID: 38862008. View here
Consideration of Metastasis-Directed Therapy for Patients With Metastatic Colorectal Cancer: Expert Survey and Systematic Review. Eric D. Miller, Brett G. Klamer, Jordan M. Cloyd, Timothy M. Pawlik, Terence M. Williams, Kathryn E. Hitchcock, Paul B. Romesser, Harvey J. Mamon, Kimmie Ng, Sepideh Gholami, George J. Chang, Christopher J. Anker. Clinical colorectal cancer. Jun 2024 23(2) 160-173. doi: 10.1016/j.clcc.2024.01.004. PMID: 38365567. View here
Total Neoadjuvant Therapy for Rectal Cancer: Which Regimens to Use?. Kentaro Ochiai, Neal Bhutiani, Atsushi Ikeda, Abhineet Uppal, Michael Geoffrey White, Oliver Peacock, Craig A. Messick, Brian K. Bednarski, Yi Qian Nancy You, John M. Skibber, George J Chang, Tsuyoshi Konishi. Cancers. Jun 2024 16(11) 2093. doi: 10.3390/cancers16112093. PMID: . View here
Baseline characteristics and recruitment for SWOG S1820: altering intake, managing bowel symptoms in survivors of rectal cancer (AIMS-RC). Virginia Sun, Cynthia A. Thomson, Tracy E. Crane, Kathryn B. Arnold, Katherine A. Guthrie, Sarah G. Freylersythe, Christa Braun-Inglis, Lee Jones, Joseph C. Carmichael, Craig Messick, Devin Flaherty, Samir Ambrale, Stacey A. Cohen, Robert S. Krouse. Supportive Care in Cancer. Jun 2024 32(6) 371. doi: 10.1007/s00520-024-08527-x. PMID: 38775966. View here
Testing Machine Learning Models to Predict Postoperative Ileus after Colorectal Surgery. Garry Brydges, George J. Chang, Tong J. Gan, Tsuyoshi Konishi, Vijaya Gottumukkala, Abhineet Uppal. Current Oncology. Jun 2024 31(6) 3563-3578. doi: 10.3390/curroncol31060262. PMID: 38920745. View here
Application of Machine Learning in Predicting Perioperative Outcomes in Patients with Cancer: A Narrative Review for Clinicians. Garry Brydges, Abhineet Uppal, Vijaya Gottumukkala. Current Oncology. May 2024 31(5) 2727-2747. doi: 10.3390/curroncol31050207. PMID: 38785488. View here
Modifier 22 Use in Fee-for-Service Medicare. Christopher P. Childers, Naveen V. Manisundaram, Chung Yuan Hu, George J. Chang. JAMA Surgery. May 2024 159(5) 563-569. doi: 10.1001/jamasurg.2024.0048. PMID: 38506853. View here
Automated, High-Throughput Platform to Generate a High-Reliability, Comprehensive Rectal Cancer Database. Neal Bhutiani, Mahmoud M.G. Yousef, Abdelrahman Yousef, Mohammad Zeineddine, Mark Knafl, Olivia Ratliff, Uditha P. Fernando, Anastasia Turin, Fadl A. Zeineddine, Jeff Jin, Kristin Alfaro-Munoz, Drew Goldstein, George J Chang, Scott Kopetz, John Paul Y.C. Shen, Abhineet Uppal. JCO Clinical Cancer Informatics. May 2024 8() e2300219. doi: 10.1200/CCI.23.00219. PMID: 38759125. View here
Multi-Institutional Study Evaluating the Role of Circulating Tumor DNA in the Management of Appendiceal Cancers. Erika Belmont, Varun V. Bansal, Mahmoud M.G. Yousef, Mohammad A. Zeineddine, David Su, Ankit Dhiman, Chih Yi Liao, Blasé Polite, Oliver S. Eng, Keith F. Fournier, Michael Geoffrey White, Kiran K. Turaga, Jo Shen. JCO Precision Oncology. May 2024 8() e2300531. doi: 10.1200/PO.23.00531. PMID: 38723230. View here
The current multidisciplinary management of rectal cancer. Neal Bhutiani, Oliver Peacock, Abhineet Uppal, Y. Nancy You, Brian K. Bednarski, John M. Skibber, Craig Messick, Michael G. White, George J. Chang, Tsuyoshi Konishi. Annals of Gastroenterological Surgery. May 2024 8(3) 394-400. doi: 10.1002/ags3.12777. PMID: . View here
Perioperative and oncological outcomes following robotic en bloc multivisceral resection for colorectal cancer. Sandra R. DiBrito, Naveen Manisundaram, Youngwan Kim, Oliver Peacock, Chung Yuan Hu, Brian Bednarski, Y. Nancy You, Abhineet Uppal, Matthew Tillman, Tsuyoshi Konishi, Harmeet Kaur, Sarah Palmquist, Emma Holliday, D. Colorectal Disease. May 2024 26(5) 949-957. doi: 10.1111/codi.16964. PMID: 38576073. View here
Prognostic factors of para-aortic lymph node metastasis from colorectal cancer in highly selected patients undergoing para-aortic lymph node dissection. Shin Emoto, Yosuke Fukunaga, Manabu Takamatsu, Hiroshi Kawachi, Shuhei Sano, Tetsuro Tominaga, Toshiki Mukai, Tomohiro Yamaguchi, Toshiya Nagasaki, Takashi Akiyoshi, Tsuyoshi Konishi, Satoshi Nagayama, Masashi Ueno. Surgery Today. Apr 2024 54(4) 356-366. doi: 10.1007/s00595-023-02739-0. PMID: 37648781. View here
Evolving survival gains in patients with young-onset colorectal cancer and synchronous resectable liver metastases. Harufumi Maki, Antony Haddad, Mateo Lendoire, Timothy E. Newhook, Oliver Peacock, Brian K. Bednarski, Tsuyoshi Konishi, Jean Nicolas Vauthey, Y. Nancy You. European Journal of Surgical Oncology. Apr 2024 50(4) 108057. doi: 10.1016/j.ejso.2024.108057. PMID: 38461567. View here
Identification of colorectal cancer cell stemness from single-cell RNA sequencing. Kangyu Lin, Saikat Chowdhury, Mohammad A. Zeineddine, Fadl A. Zeineddine, Nicholas J. Hornstein, Oscar E. Villarreal, Dipen M. Maru, Cara L. Haymaker, Jean Nicolas Vauthey, George J Chang, Elena Bogatenkova, Davi Menter. Molecular Cancer Research. Apr 2024 22(4) . doi: 10.1158/1541-7786.MCR-23-0468. PMID: 38156967. View here
The value of national accreditation program for rectal cancer: A survey of accredited programs and programs seeking accreditation. Muneera R. Kapadia, Peter J. Senatore, Craig Messick, Tracy L. Hull, Virginia O. Shaffer, Arden M. Morris, David W. Dietz, Steven D. Wexner, Elizabeth C. Wick. Surgery (United States). Apr 2024 175(4) 1007-1012. doi: 10.1016/j.surg.2023.12.005. PMID: 38267342. View here
Immuno-Oncology: New Insights into Targets and Therapies. Shiruyeh Schokrpur, Michael G. White, Christina L. Roland, Sandip Pravin Patel. Surgical oncology clinics of North America. Apr 2024 33(2) 265-278. doi: 10.1016/j.soc.2023.12.006. PMID: 38401909. View here
Characteristics of Health Care Settings Where Adolescents and Young Adults Receive Care for ALL. Julie A. Wolfson, Allison C. Grimes, Michelle Nuno, Charlotte L. Kerber, Subhash Ramakrishnan, Melissa Beauchemin, David Dickens, Jennifer M. Levine, Michael E. Roth, Michele Scialla, Wendy Woods, Sarah Vargas, Boayue. JCO Oncology Practice. Apr 2024 20(4) 491-502. doi: 10.1200/OP.23.00328. PMID: 38252911. View here
Metastasis and the Microbiome: The Impact of Bacteria in Disseminated Colorectal Cancer. Reed I. Ayabe, Michael G. White. Frontiers in Bioscience - Landmark. Apr 2024 29(4) 12904152. doi: 10.31083/j.fbl2904152. PMID: 38682201. View here
Salvage Treatment of Recurrent or Persistent Anal Squamous Cell Carcinoma: The Role of Multi-modality Therapy. Ethan P. Damron, Jordan McDonald, Michael K. Rooney, Prajnan Das, Ethan B. Ludmir, Bruce D. Minsky, Craig Messick, George J. Chang, Van K. Morris, Emma B. Holliday. Clinical colorectal cancer. Mar 2024 23(1) 85-94. doi: 10.1016/j.clcc.2023.12.002. PMID: 38216367. View here
Daily Vaginal Dilator Use During Radiation for Women With Squamous Cell Carcinoma of the Anus: Vaginal Wall Dosimetry and Patient-Reported Sexual Function. Angelica Arzola, Enoch Chang, Michael K. Rooney, Kelsey Corrigan, Prajnan Das, Ethan B. Ludmir, Eugene J. Koay, Bruce D. Minsky, Grace L. Smith, Craig Messick, Van K. Morris, Denise Nebgen, Christopher H. Crane, Emma B. Holliday. Practical radiation oncology. Mar 2024 14(2) e105-e116. doi: 10.1016/j.prro.2023.10.002. PMID: 37898354. View here
The empty pelvis syndrome: a core data set from the PelvEx collaborative. PelvEx Collaborative, Charles T. West, M. A. West, A. H. Mirnezami, I. Drami, T. Glyn, P. A. Sutton, J. Tiernan, C. Behrenbruch, G. Guerra, P. S. Waters, N. Woodward, S. Applin, S. J. Charles, S. A. Rose, A. Denys. British Journal of Surgery. Mar 2024 111(3) znae042. doi: 10.1093/bjs/znae042. PMID: 38456677. View here
Lung surveillance following colorectal cancer pulmonary metastasectomy: Utilization of clinicopathologic risk factors to guide strategy. Nathaniel Deboever, Erin M. Bayley, Michael A. Eisenberg, Wayne L. Hofstetter, Reza J. Mehran, David C. Rice, Ravi Rajaram, Jack A. Roth, Boris Sepesi, Stephen G. Swisher, Ara A. Vaporciyan, Garrett L. Walsh, Brian K. Bednarski, Van K. Morris, Mara B. Antonoff. Journal of Thoracic and Cardiovascular Surgery. Mar 2024 167(3) 814-819.e2. doi: 10.1016/j.jtcvs.2023.07.017. PMID: 37495170. View here
Do resected colorectal cancer patients need early chest imaging? Impact of clinicopathologic characteristics on time to development of pulmonary metastases. Nathaniel Deboever, Erin M. Bayley, Michael A. Eisenberg, Wayne L. Hofstetter, Reza J. Mehran, David C. Rice, Ravi Rajaram, Jack A. Roth, Boris Sepesi, Stephen G. Swisher, Ara A. Vaporciyan, Garrett L. Walsh, Brian K. Bednarski, Van K. Morris, Mara B. Antonoff. Journal of surgical oncology. Feb 2024 129(2) 331-337. doi: 10.1002/jso.27490. PMID: 37876311. View here
Androgen drives melanoma invasiveness and metastatic spread by inducing tumorigenic fucosylation. Qian Liu, Emma Adhikari, Daniel K. Lester, Bin Fang, Joseph O. Johnson, Yijun Tian, Andrea T. Mockabee-Macias, Victoria Izumi, Kelly M. Guzman, Michael G. White, John M. Koomen, Jennifer A. Wargo, Jane L. Messina, Jianfei Qi, Eric K. Lau. Nature communications. Feb 2024 15(1) 1148. doi: 10.1038/s41467-024-45324-w. PMID: 38326303. View here
Invited Commentary. Selective lateral pelvic lymph node dissection in low rectal cancer—Planning for future directions. Tom Pampiglione, Tsuyoshi Konishi, Manish Chand. Surgery (United States). Feb 2024 175(2) 564-565. doi: 10.1016/j.surg.2023.11.003. PMID: 38052676. View here
Serum Tumor Markers and Outcomes in Patients With Appendiceal Adenocarcinoma. Abdelrahman Yousef, Mahmoud Yousef, Mohammad A. Zeineddine, Aditya More, Mohammad Fanaeian, Saikat Chowdhury, Mark Knafl, Paul Edelkamp, Ichiaki Ito, Yue Gu, Vinay Pattalachinti, Zahra Alavi Naini, Fadl A. Zeineddine. JAMA Network Open. Feb 2024 7(2) e240260. doi: 10.1001/jamanetworkopen.2024.0260. PMID: 38416491. View here
Beating the empty pelvis syndrome: the PelvEx Collaborative core outcome set study protocol. PelvEx Collaborative, C. T. West, M. A. West, I. Drami, A. Denys, T. Glyn, P. A. Sutton, J. Tiernan, C. Behrenbruch, G. Guerra, P. S. Waters, N. Woodward, S. Applin, S. J. Charles, S. A. Rose, E. Pape, G. H. van Ramshorst, A. H. Mirnezami, A. G.J. Aalbers, N. Abdul Aziz, N. Abecasis, M. Abraham-Nordling, T. Akiyoshi, R. Alahmadi, W. Alberda, M. Albert, M. Andric, M. Angeles, E. Angenete, A. Antoniou, J. Armitage, R. Auer, K. K. Austin, E. Aytac, O. Aziz, N. Bacalbasa, R. P. Baker, M. Bali, S. Baransi, G. Baseckas, B. Bebington, M. Bedford, B. K. Bednarski, G. L. Beets, P. L. Berg, C. Bergzoll, J. Beynon, S. Biondo, K. Boyle, L. Bordeianou, G. Chang. BMJ open. Feb 2024 14(2) e076538. doi: 10.1136/bmjopen-2023-076538. PMID: 38316595. View here
Repeat Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for Recurrent Mucinous Appendiceal Adenocarcinoma: A Viable Treatment Strategy with Demonstrable Benefit. Neal Bhutiani, Travis E. Grotz, Seth J. Concors, Michael G. White, Beth A. Helmink, Kanwal P. Raghav, Melissa W. Taggart, Karen A. Beaty, Richard E. Royal, Michael J. Overman, Aurelio Matamoros, Christopher P. Scally, Safia Rafeeq, Paul F. Mansfield, Keith F. Fournier. Annals of surgical oncology. Jan 2024 31(1) 614-621. doi: 10.1245/s10434-023-14422-2. PMID: 37872456. View here
2023
Validation of an endoscopic anastomotic grading score as an intraoperative method for assessing stapled rectal anastomoses. C. Farzaneh, A. Uppal, M. D. Jafari, W. Q. Duong, J. C. Carmichael, S. D. Mills, M. J. Stamos, A. Pigazzi. Techniques in Coloproctology. Dec 2023 27(12) 1235-1242. doi: 10.1007/s10151-023-02797-z. PMID: 37184769. View here
Young-onset colorectal cancer. Manon C.W. Spaander, Ann G. Zauber, Sapna Syngal, Martin J. Blaser, Joseph J. Sung, Y. Nancy You, Ernst J. Kuipers. Nature Reviews Disease Primers. Dec 2023 9(1) 21. doi: 10.1038/s41572-023-00432-7. PMID: 37105987. View here
Stoma-free survival after anastomotic leak following rectal cancer resection: worldwide cohort of 2470 patients. TENTACLE - Rectum Collaborators, Nynke G. Greijdanus, Kiedo Wienholts, Sander Ubels, Kevin Talboom, Gerjon Hannink, Albert Wolthuis, F. Borja de Lacy, Jérémie H. Lefevre, Michael Solomon, Matteo Frasson, Nicolas Rotholtz, Quentin Denost, Rodrigo O. Perez, Tsuyoshi Konishi, Yves Panis, Martin Rutegård, Roel Hompes, Camiel Rosman, Frans van Workum, Pieter J. Tanis, Johannes H.W. de Wilt, Andreas J.A. Bremers, Floris T. Ferenschild, Stefanie de Vriendt, André D'Hoore, Gabriele Bislenghi, Jordi Farguell, Antonio M. Lacy, Paula González Atienza, Charlotte S. van Kessel, Yann Parc, Thibault Voron, Maxime K. Collard, Jorge Sancho Muriel, Hannia Cholewa, Laura A. Mattioni, Alice Frontali, Sebastiaan W. Polle, Fatih Polat, Ndidi J. Obihara, Bruna B. Vailati, Miranda Kusters, Jurriaan B. Tuynmann, Sanne J.A. Hazen, Alexander A.J. Gruter, Takahiro Amano, Hajime Fujiwara, Mario Salomon, Hernan Ruiz, Ricardo Gonzalez. British Journal of Surgery. Dec 2023 110(12) 1863-1876. doi: 10.1093/bjs/znad311. PMID: 37819790. View here
Empty pelvis syndrome: PelvEx Collaborative guideline proposal. PelvicEx Collaborative, Charles T. West, C. T. West, M. A. West, A. H. Mirnezami, I. Drami, A. Denys, T. Glyn, P. A. Sutton, J. Tiernan, C. Behrenbruch, G. Guerra, P. S. Waters, N. Woodward, S. Applin, S. J. Charles, S. A. Rose, E. Pape, G. H. van Ramshorst, A. G.J. Aalbers, N. Abdul Aziz, N. Abecasis, M. Abraham-Nordling, T. Akiyoshi, R. Alahmadi, W. Alberda, M. Albert, M. Andric, M. Angeles, E. Angenete, A. Antoniou, J. Armitage, R. Auer, K. K. Austin, E. Aytac, O. Aziz, N. Bacalbasa, R. P. Baker, M. Bali, S. Baransi, G. Baseckas, B. Bebington, M. Bedford, B. K. Bednarski, G. L. Beets, P. L. Berg, C. Bergzoll, S. Biondo, K. Boyle, K. Flatmark, S. G. Larsen. British Journal of Surgery. Dec 2023 110(12) 1730-1731. doi: 10.1093/bjs/znad301. PMID: 37757457. View here
ASO Visual Abstract: Treatment Variation and Long-Term Outcomes of Low-Grade Appendiceal Neoplasms. Michael G. White, Neal Bhutiani, Beth A. Helmink, Melissa Taggart, Wai Chin Foo, Paul F. Mansfield, Keith F. Fournier, Christopher P. Scally. Annals of surgical oncology. Dec 2023 30(13) 8176. doi: 10.1245/s10434-023-13556-7. PMID: 37728822. View here
Treatment Variation and Long-Term Outcomes of Low-Grade Appendiceal Neoplasms. Michael Geoffrey White, Neal Bhutiani, Beth A. Helmink, Melissa Taggart, Wai Chin Foo, Paul F Mansfield, Keith F. Fournier, Christopher Patrick Scally. Annals of surgical oncology. Dec 2023 30(13) 8138-8143. doi: 10.1245/s10434-023-13501-8. PMID: 37702905. View here
Utility of Circulating Tumor DNA in Appendiceal Tumors. Neal Bhutiani, Beth A. Helmink, Mohammad Zeineddine, Abhineet Uppal, John Paul Shen, Erik Spickard, Michael G. White. Journal of Gastrointestinal Surgery. Dec 2023 27(12) 3071-3073. doi: 10.1007/s11605-023-05825-3. PMID: 37709990. View here
ASO Author Reflections: Contemporary Management of Low-Grade Appendiceal Mucinous Neoplasms. Michael G. White, Christopher P. Scally. Annals of surgical oncology. Dec 2023 30(13) 8168-8169. doi: 10.1245/s10434-023-13523-2. PMID: 37231292. View here
Stoma-free Survival After Rectal Cancer Resection With Anastomotic Leakage: Development and Validation of a Prediction Model in a Large International Cohort. Nynke G. Greijdanus, Kiedo Wienholts, Sander Ubels, Kevin Talboom, Gerjon Hannink, Albert Wolthuis, Francisco B. De Lacy, Jérémie H. Lefevre, Michael Solomon, Matteo Frasson, Nicolas Rotholtz, Quentin Denost, Rodrigo O. Perez, Tsuyoshi Konishi, Yves Panis, Martin Rutegård, Roel Hompes, Camiel Rosman, Frans Van Workum, Pieter J. Tanis, Johannes H.W. De Wilt. Annals of surgery. Nov 2023 278(5) 772-780. doi: 10.1097/SLA.0000000000006043. PMID: 37498208. View here
Reporting of Circumferential Resection Margin in Rectal Cancer Surgery. Naveen Manisundaram, Sandra R. DiBrito, Chung Yuan Hu, Youngwan Kim, Elizabeth Wick, Bryan Palis, Oliver Peacock, George J. Chang. JAMA Surgery. Nov 2023 158(11) 1195-1202. doi: 10.1001/jamasurg.2023.4221. PMID: 37728906. View here
Communication Frameworks for Palliative Surgical Consultations: A Randomized Study of Advanced Cancer Patients. Alisa N. Blumenthaler, Kristen Ashlee Robinson, Caitlin Hodge, Lianchun Xiao, Elizabeth J. Lilley, James F. Griffin, Michael G. White, Ryan Day, Kimberson Tanco, Eduardo Bruera, Brian D. Badgwell. Annals of surgery. Nov 2023 278(5) E1110- E1117. doi: 10.1097/SLA.0000000000005823. PMID: 36806227. View here
Decreasing Environmental Operating Room Chemotherapy Levels Following Heated Intraperitoneal Chemotherapy (HIPEC) Through Implementation of Standard Protocols. Neal Bhutiani, Michael G. White, Bradford J. Kim, Christopher P. Scally, Beth A. Helmink, Paul F. Mansfield, Keith F. Fournier, Richard E. Royal. Annals of surgical oncology. Nov 2023 30(12) 6981-6982. doi: 10.1245/s10434-023-13409-3. PMID: 37624514. View here
Endoscopic and imaging outcomes of PD-1 therapy in localised dMMR colorectal cancer. Daniel A. Fox, Deepak Bhamidipati, Tsuyoshi Konishi, Harmeet Kaur, Nancy You, Kanwal P.S. Raghav, Phillip S. Ge, Craig Messick, Benny Johnson, Van K. Morris, Jane V. Thomas, Preksha Shah, Brian K. Bednarski, Scott Kopetz, George J. Chang, Kaysia Ludford, Victoria Serpas Higbie, Michael J. Overman. European Journal of Cancer. Nov 2023 194() 113356. doi: 10.1016/j.ejca.2023.113356. PMID: 37827065. View here
Intraperitoneal Paclitaxel Is a Safe and Effective Therapeutic Strategy for Treating Mucinous Appendiceal Adenocarcinoma. Ichiaki Ito, Abdelrahman M.G. Abdelrahman, Saikat Chowdhury, Princess N. Dickson, Zahra A. Naini, Michael Geoffrey White, Karianne G. Fleten, Kjersti Flatmark, Keith F. Fournier, Natalie W. Fowlkes, John Paul Y.C. Shen. Cancer Research. Oct 2023 83(19) 3184-3191. doi: 10.1158/0008-5472.CAN-23-0013. PMID: 37433032. View here
Lessons learned from conducting the first cancer care delivery trial in the Alliance for Clinical Trials in Oncology (Alliance A191402CD). Joel E. Pacyna, Amylou C. Dueck, George J. Chang, Selina Chow, Electra D. Paskett, Simon Kim, Jon C. Tilburt. Clinical Trials. Oct 2023 20(5) 559-563. doi: 10.1177/17407745231167123. PMID: 37050880. View here
Young-onset Rectal Cancer: Unique Tumoral Microbiome and Correlation With Response to Neoadjuvant Therapy. Michael G. White, Ashish Damania, Jumanah Alshenaifi, Pranoti Sahasrabhojane, Oliver Peacock, Jillian Losh, Matthew C. Wong, Zuzana Lutter-Berkova, George J. Chang, Andrew Futreal, Jennifer A. Wargo, Nadim J. Ajami, Scott Kopetz, Y. Nancy You. Annals of surgery. Oct 2023 278(4) 538-548. doi: 10.1097/SLA.0000000000006015. PMID: 37465976. View here
ASO Visual Abstract: Hepatectomy Before Primary Tumor Resection as the Preferred Approach for Synchronous Liver Metastases from Rectal Cancer. Harufumi Maki, Reed I. Ayabe, Yujiro Nishioka, Tsuyoshi Konishi, Timothy E. Newhook, Hop S. Tran Cao, Yun Shin Chun, Ching Wei D. Tzeng, Y. Nancy You, Jean Nicolas Vauthey. Annals of surgical oncology. Sep 2023 30(9) 5403-5404. doi: 10.1245/s10434-023-13762-3. PMID: 37358681. View here
Evaluation of National Surgical Practice for Lateral Lymph Nodes in Rectal Cancer in an Untrained Setting: Time to Collaborate for Universal Consensus and Training Programs. Tsuyoshi Konishi. Annals of surgical oncology. Sep 2023 30(9) 5320-5322. doi: 10.1245/s10434-023-13540-1. PMID: 37115373. View here
ASO Author Reflections: The Patient First Approach for Synchronous Liver Metastases from Rectal Cancer. Harufumi Maki, Reed I. Ayabe, Yujiro Nishioka, Tsuyoshi Konishi, Timothy E. Newhook, Hop S. Tran Cao, Yun Shin Chun, Ching Wei D. Tzeng, Y. Nancy You, Jean Nicolas Vauthey. Annals of surgical oncology. Sep 2023 30(9) 5401-5402. doi: 10.1245/s10434-023-13767-y. PMID: 37322282. View here
Correction: Hepatectomy Before Primary Tumor Resection as Preferred Approach for Synchronous Liver Metastases from Rectal Cancer (Annals of Surgical Oncology, (2023), 30, 9, (5390- 5400), 10.1245/s10434-023-13656-4). Harufumi Maki, Reed I. Ayabe, Yujiro Nishioka, Tsuyoshi Konishi, Timothy E. Newhook, Hop S. Tran Cao, Yun Shin Chun, Ching Wei D. Tzeng, Y. Nancy You, Jean Nicolas Vauthey. Annals of surgical oncology. Sep 2023 30(9) 5405. doi: 10.1245/s10434-023-13769-w. PMID: 37344750. View here
Hepatectomy Before Primary Tumor Resection as Preferred Approach for Synchronous Liver Metastases from Rectal Cancer. Harufumi Maki, Reed I. Ayabe, Yujiro Nishioka, Tsuyoshi Konishi, Timothy E. Newhook, Hop S. Tran Cao, Yun Shin Chun, Ching Wei D. Tzeng, Y. Nancy You, Jean Nicolas Vauthey. Annals of surgical oncology. Sep 2023 30(9) 5390-5400. doi: 10.1245/s10434-023-13656-4. PMID: 37285096. View here
MDT—How it is important in rectal cancer. Brian K. Bednarski, Melissa Taggart, George J. Chang. Abdominal Radiology. Sep 2023 48(9) 2807-2813. doi: 10.1007/s00261-023- 03977-z. PMID: 37393382. View here
The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Reduction of Venous Thromboembolic Disease in Colorectal Surgery. Sunil V. Patel, Sender A. Liberman, Pamela L. Burgess, Joel E. Goldberg, Vitaliy Y. Poylin, Craig A. Messick, Bradley R. Davis, Daniel L. Feingold, Amy L. Lightner, Ian M. Paquette. Diseases of the colon and rectum. Sep 2023 66(9) 1162-1173. doi: 10.1097/DCR.0000000000002975. PMID: 37318130. View here
International standardization and optimization group for intersphincteric resection (ISOG-ISR): modified Delphi consensus on anatomy, definition, indication, surgical technique, specimen description and functional outcome. Guglielmo Niccolò Piozzi, Krunal Khobragade, Vusal Aliyev, Oktar Asoglu, Paolo Pietro Bianchi, Vlad Olimpiu Butiurca, William Tzu Liang Chen, Ju Yong Cheong, Gyu Seog Choi, Andrea Coratti, Quentin Denost, Yosuke Fukunaga, Emre Gorgun, Francesco Guerra, Masaaki Ito, Jim S. Khan, Hye Jin Kim, Jin Cheon Kim, Yusuke Kinugasa, Tsuyoshi Konishi, Li Jen Kuo, Mehmet Ayhan Kuzu, Jeremie H. Lefevre, Jin Tung Liang, John Marks, Călin Molnar, Yves Panis, Philippe Rouanet, Eric Rullier, Avanish Saklani, Antonino Spinelli, Petr Tsarkov, Shunsuke Tsukamoto, Martin Weiser, Seon Hahn Kim. Colorectal Disease. Sep 2023 25(9) 1896-1909. doi: 10.1111/codi.16704. PMID: 37563772. View here
ASO Visual Abstract: Adding Induction Chemotherapy Before Chemoradiotherapy with Total Mesorectal Excision and Selective Lateral Lymph Node Dissection in Patients with Poor-Risk, Locally Advanced, Mid-to-Low Rectal Cancer May Improve Oncological Outcomes-. Tomohiro Yamaguchi, Takashi Akiyoshi, Yosuke Fukunaga, Takashi Sakamoto, Toshiki Mukai, Yukiharu Hiyoshi, Toshiya Nagasaki, Senzo Taguchi, Akiko Chino, Eiji Shinozaki, Kensei Yamaguchi, Tsuyoshi Konishi. Annals of surgical oncology. Aug 2023 30(8) 4727-4728. doi: 10.1245/s10434-023-13481-9. PMID: 37118614. View here
Adding Induction Chemotherapy Before Chemoradiotherapy with Total Mesorectal Excision and Selective Lateral Lymph Node Dissection for Patients with Poor-Risk, Locally Advanced, Mid-to-Low Rectal Cancer May Improve Oncologic Outcomes: A Propensity Score-Ma. Tomohiro Yamaguchi, Takashi Akiyoshi, Yosuke Fukunaga, Takashi Sakamoto, Toshiki Mukai, Yukiharu Hiyoshi, Toshiya Nagasaki, Senzo Taguchi, Akiko Chino, Eiji Shinozaki, Kensei Yamaguchi, Tsuyoshi Konishi. Annals of surgical oncology. Aug 2023 30(8) 4716-4724. doi: 10.1245/s10434-023-13458-8. PMID: 37032405. View here
Prognostic factors of para-aortic lymph node metastasis from colorectal cancer in highly selected patients undergoing para-aortic lymph node dissection. Shin Emoto, Yosuke Fukunaga, Manabu Takamatsu, Hiroshi Kawachi, Shuhei Sano, Tetsuro Tominaga, Toshiki Mukai, Tomohiro Yamaguchi, Toshiya Nagasaki, Takashi Akiyoshi, Tsuyoshi Konishi, Satoshi Nagayama, Masashi Ueno. Surgery Today. Online ahead of print 8/30/2023. doi: 10.1007/s00595-023-02739-0. View here
ASO Author Reflections: Oncological Outcomes of Adding Induction Chemotherapy Before Chemoradiotherapy with Total Mesorectal Excision and Selective Lateral Lymph Node Dissection in Patients with Poor-Risk, Locally Advanced Rectal Cancer. Tomohiro Yamaguchi, Takashi Akiyoshi, Tsuyoshi Konishi. Annals of surgical oncology. Aug 2023 30(8) 4725-4726. doi: 10.1245/s10434-023-13462-y. PMID: 37036587. View here
Therapeutic lateral pelvic lymph node dissection in rectal cancer: when to dissect? Size is not everything. Oliver Peacock, Naveen Manisundaram, Youngwan Kim, Tsuyoshi Konishi, Nir Stanietzky, Raghunandan Vikram, Brian K. Bednarski, Y. Nancy You, George J. Chang. British Journal of Surgery. Aug 2023 110(8) 985-986. doi: 10.1093/bjs/znad115. PMID: 37150892. View here
Patient-Reported Outcomes during and after Treatment for Locally Advanced Rectal Cancer in the PROSPECT Trial (Alliance N1048). Ethan Basch, Amylou C. Dueck, Sandra A. Mitchell, Harvey Mamon, Martin Weiser, Leonard Saltz, Marc Gollub, Lauren Rogak, Brenda Ginos, Gina L. Mazza, Brian Colgrove, George Chang, Lori Minasian, Andrea Denicoff, Gita Thanarajasingam, Benjamin Musher, Thomas George, Alan Venook, Jeffrey Farma, Eileen O'Reilly, Jeffrey A. Meyerhardt, Qian Shi, Deborah Schrag. Journal of Clinical Oncology. Jul 2023 41(21) 3724-3734. doi: 10.1200/JCO.23.00903. PMID: 37270691. View here
Patient-reported Bowel Function and Bowel-related Quality of Life After Pelvic Radiation for Rectal Adenocarcinoma: The Impact of Radiation Fractionation and Surgical Resection. Michael K. Rooney, Brian De, Kelsey Corrigan, Grace L. Smith, Cullen Taniguchi, Bruce D. Minsky, Ethan B. Ludmir, Eugene J. Koay, Prajnan Das, Albert C. Koong, Oliver Peacock, George Chang, Y. Nancy You, Van K. Morris, Graciela Nogueras-González, Emma B. Holliday. Clinical colorectal cancer. Jun 2023 22(2) 211-221. doi: 10.1016/j.clcc.2023.02.003. PMID: 36878805. View here
ASO Visual Abstract: Insurance Disparities in Access to Robotic Surgery for Colorectal Cancer. Christopher P. Childers, Abhineet Uppal, Matthew Tillman, George J. Chang, Hop S. Tran Cao. Annals of surgical oncology. Jun 2023 30(6) 3569. doi: 10.1245/s10434-023-13454-y. PMID: 37052830. View here
Insurance Disparities in Access to Robotic Surgery for Colorectal Cancer. Christopher P. Childers, Abhineet Uppal, Matthew Tillman, George J. Chang, Hop S. Tran Cao. Annals of surgical oncology. Jun 2023 30(6) 3560-3568. doi: 10.1245/s10434-023-13354-1. PMID: 36943527. View here
Efficacy of Systemic Chemotherapy in Patients With Low-grade Mucinous Appendiceal Adenocarcinoma: A Randomized Crossover Trial. John Paul Shen, Abdelrahman M. Yousef, Fadl A. Zeineddine, Mohammad A. Zeineddine, Rebecca S. Tidwell, Karen A. Beaty, Lisa C. Scofield, Safia Rafeeq, Nicholas Hornstein, Elizabeth Lano, Cathy Eng, Aurelio Matamoros, Wai Chin Foo, Abhineet Uppal, Christopher Scally, Paul Mansfield, Melissa Taggart, Kanwal P. Raghav, Michael J. Overman, Keith Fournier. JAMA Network Open. Jun 2023 6(6) e2316161. doi: 10.1001/jamanetworkopen.2023.16161. PMID: 37261831. View here
Anal Carcinoma, Version 2.2023. Al B. Benson, Alan P. Venook, Mahmoud M. Al-Hawary, Nilofer Azad, Yi Jen Chen, Kristen K. Ciombor, Stacey Cohen, Harry S. Cooper, Dustin Deming, Ignacio Garrido-Laguna, Jean L. Grem, J. Randolph Hecht, Sarah Hoffe, Joleen Hubbard, Steven Hunt, Hisham Hussan, William Jeck, Kimberly L. Johung, Nora Joseph, Natalie Kirilcuk, Smitha Krishnamurthi, Jennifer Maratt, Wells A. Messersmith, Jeffrey Meyerhardt, Eric D. Miller, Mary F. Mulcahy, Steven Nurkin, Michael J. Overman, Aparna Parikh, Hitendra Patel, Katrina Pedersen, Leonard Saltz, Charles Schneider, David Shibata, John M. Skibber, Constantinos T. Sofocleous, Eden Stotsky-Himelfarb, Anna Tavakkoli, Christopher G. Willett, Grant Williams, Frankie Algieri, Lisa Gurski, P. A.C. Katie Stehman. JNCCN Journal of the National Comprehensive Cancer Network. Jun 2023 21(6) 653-677. doi: 10.6004/jnccn.2023.0030. PMID: 37308125. View here
The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Fecal Incontinence. Liliana G. Bordeianou, Amy J. Thorsen, Deborah S. Keller, Alexander T. Hawkins, Craig Messick, Lucia Oliveira, Daniel L. Feingold, Amy L. Lightner, Ian M. Paquette. Diseases of the colon and rectum. May 2023 66(5) 647-661. doi: 10.1097/DCR.0000000000002776. PMID: 36799739. View here
Prospective Study of Perioperative Circulating Tumor DNA Dynamics in Patients Undergoing Hepatectomy for Colorectal Liver Metastases. Timothy E. Newhook, Michael J. Overman, Yun Shin Chun, Arvind Dasari, Ching Wei D. Tzeng, Hop S.Tran Cao, Victoria Raymond, Christine Parseghian, Benny Johnson, Yujiro Nishioka, Yoshikuni Kawaguchi, Abhineet Uppal, Timothy J. Vreeland, Ariel Jaimovich, Elsa M. Arvide, Jenilette V. Cristo, Steven H. Wei, Kanwal P. Raghav, Van K. Morris, Jeffrey E. Lee, Scott Kopetz, Jean Nicolas Vauthey. Annals of surgery. May 2023 277(5) 813-820. doi: 10.1097/SLA.0000000000005461. PMID: 35797554. View here
Germline Cancer Risk Profiles of Patients With Young-Onset Colorectal Cancer: Findings From a Prospective Universal Germline Testing and Telegenetics Program. Y. Nancy You, Julie B. Moskowitz, George J. Chang, Maureen E. Mork, Miguel A. Rodriguez-Bigas, Brian K. Bednarski, Craig A. Messick, Matthew M. Tillman, John M. Skibber, Sa T. Nguyen, Scott Kopetz, Eduardo Vilar. Diseases of the colon and rectum. Apr 2023 66(4) 531-542. doi: 10.1097/DCR.0000000000002347. PMID: 35195555. View here
Neoadjuvant Pembrolizumab in Localized Microsatellite Instability High/Deficient Mismatch Repair Solid Tumors. Kaysia Ludford, Won Jin Ho, Jane V. Thomas, Kanwal P.S. Raghav, Mariela Blum Murphy, Nicole D. Fleming, Michael S. Lee, Brandon G. Smaglo, Y. Nancy You, Matthew M. Tillman, Carlos Kamiya-Matsuoka, Selvi Thirumurthi, Craig Messick, Benny Johnson, Eduardo Vilar, Arvind Dasari, Sarah Shin, Alexei Hernandez, Xuan Yuan, Hongqui Yang, Wai Chin Foo, Wei Qiao, Dipen Maru, Scott Kopetz, Michael J. Overman. Journal of Clinical Oncology. Apr 2023 41(12) 2181-2190. doi: 10.1200/JCO.22.01351. PMID: 36623241. View here
Expert Commentary on Lateral Pelvic Sidewall Nodes. George J. Chang. Diseases of the colon and rectum. Mar 2023 66(3) 358-359. doi: 10.1097/DCR.0000000000002717. PMID: 36728390. View here
Impact of cumulative operative time on postoperative complication risk in simultaneous resections of colorectal liver metastases and primary tumors. Allison N. Martin, Ching Wei D. Tzeng, Elsa M. Arvide, John M. Skibber, George J. Chang, Yi Qian Nancy You, Brian K. Bednarski, Abhineet Uppal, Whitney L. Dewhurst, Jenilette V. Cristo, Yun S. Chun, Hop S. Tran Cao, Jean Nicolas Vauthey, Timothy E. Newhook. HPB. Mar 2023 25(3) 347-352. doi: 10.1016/j.hpb.2022.12.008. PMID: 36697350. View here
Peritoneal recurrence after resection for Stage I–III colorectal cancer: A population analysis. Taylor Aiken, Chung Yuan Hu, Abhineet Uppal, Amanda B. Francescatti, Keith F. Fournier, George J. Chang, Syed Nabeel Zafar. Journal of surgical oncology. Mar 2023 127(4) 678-687. doi: 10.1002/jso.27175. PMID: 36519668. View here
Differential Spatial Gene and Protein Expression Associated with Recurrence Following Chemoradiation for Localized Anal Squamous Cell Cancer. Sharia Hernandez, Prajnan Das, Emma B. Holliday, Li Shen, Wei Lu, Benny Johnson, Craig A. Messick, Cullen M. Taniguchi, John Skibber, Ethan B. Ludmir, Y. Nancy You, Grace Li Smith, Brian Bednarski, Larisa Kostousov, Eugene J. Koay, Bruce D. Minsky, Matthew Tillman, Shaelynn Portier, Cathy Eng, Albert C. Koong, George J. Chang, Wai Chin Foo, Jing Wang, Luisa Solis Soto, Van K. Morris. Cancers. Mar 2023 15(6) 1701. doi: 10.3390/cancers15061701. PMID: 36980587. View here
The RECOURSE Study: Long-term Oncologic Outcomes Associated With Robotically Assisted Minimally Invasive Procedures for Endometrial, Cervical, Colorectal, Lung, or Prostate Cancer: A Systematic Review and Meta-analysis. Mario M. Leitao, Usha S. Kreaden, Vincent Laudone, Bernard J. Park, Emmanouil P. Pappou, John W. Davis, David C. Rice, George J. Chang, Emma C. Rossi, April E. Hebert, April Slee, Mithat Gonen. Annals of surgery. Mar 2023 277(3) 387-396. doi: 10.1097/SLA.0000000000005698. PMID: 36073772. View here
Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines. Giulia Martina Cavestro, Alessandro Mannucci, Francesc Balaguer, Heather Hampel, Sonia S. Kupfer, Alessandro Repici, Andrea Sartore-Bianchi, Toni T. Seppälä, Vincenzo Valentini, Clement Richard Boland, Randall E. Brand, Tineke E. Buffart, Carol A. Burke, Riccardo Caccialanza, Renato Cannizzaro, Stefano Cascinu, Andrea Cercek, Emma J. Crosbie, Silvio Danese, Evelien Dekker, Maria Daca-Alvarez, Francesco Deni, Mev Dominguez- Valentin, Cathy Eng, Ajay Goel, José G. Guillem, Britt B.S.L. Houwen, Charles Kahi, Matthew F. Kalady, Fay Kastrinos, Florian Kühn, Luigi Laghi, Andrew Latchford, David Liska, Patrick Lynch, Alberto Malesci, Gianluca Mauri, Elisa Meldolesi, Pål Møller, Kevin J. Monahan, Gabriela Möslein, Caitlin C. Murphy, Karlijn Nass, Kimmie Ng, Cristina Oliani, Enrico Papaleo, Swati G. Patel, Marta Puzzono, Remo. Clinical Gastroenterology and Hepatology. Mar 2023 21(3) 581-603.e33. doi: 10.1016/j.cgh.2022.12.006. PMID: 36549470. View here
The Influence of the Microbiome on Metastatic Colorectal Cancer. Samuel Cass, Michael G. White. Clinics in Colon and Rectal Surgery. Feb 2023 36(2) 112-119. doi: 10.1055/s- 0043-1760864. PMID: 36844707. View here
Fucosylation of HLA-DRB1 regulates CD4+ T cell-mediated anti-melanoma immunity and enhances immunotherapy efficacy. Daniel K. Lester, Chase Burton, Alycia Gardner, Patrick Innamarato, Krithika Kodumudi, Qian Liu, Emma Adhikari, Qianqian Ming, Daniel B. Williamson, Dennie T. Frederick, Tatyana Sharova, Michael G. White, Joseph Markowitz, Biwei Cao, Jonathan Nguyen, Joseph Johnson, Matthew Beatty, Andrea Mockabee-Macias, Matthew Mercurio, Gregory Watson, Pei Ling Chen, Susan McCarthy, Carlos MoranSegura, Jane Messina, Kerry L. Thomas, Lancia Darville, Victoria Izumi, John M. Koomen, Shari A. Pilon-Thomas, Brian Ruffell, Vincent C. Luca, Robert S. Haltiwanger, Xuefeng Wang, Jennifer A. Wargo, Genevieve M. Boland, Eric K. Lau. Nature Cancer. Feb 2023 4(2) 222-239. doi: 10.1038/s43018-022-00506-7. PMID: 36690875. View here
Transcriptomic Analyses of Pretreatment Tumor Biopsy Samples, Response to Neoadjuvant Chemoradiotherapy, and Survival in Patients with Advanced Rectal Cancer. Takashi Akiyoshi, Zhe Wang, Tomoko Kaneyasu, Osamu Gotoh, Norio Tanaka, Sayuri Amino, Noriko Yamamoto, Hiroshi Kawachi, Toshiki Mukai, Yukiharu Hiyoshi, Toshiya Nagasaki, Tomohiro Yamaguchi, Tsuyoshi Konishi, Yosuke Fukunaga, Tetsuo Noda, Seiichi Mori. JAMA Network Open. Jan 2023 6(1) E2252140. doi: 10.1001/jamanetworkopen.2022.52140. PMID: 36662520. View here
Chemotherapy and Abdominal Wall Closure Technique Increase the Probability of Postoperative Ventral Incisional Hernia in Patients With Colon Cancer. David A. Santos, Liangliang Zhang, Kim Anh Do, Brian K. Bednarski, Celia Robinson Ledet, Angela Limmer, Heather Gibson, Y. Nancy You. American Surgeon. Jan 2023 89(1) 98-107. doi: 10.1177/00031348211011149. PMID: 33877925. View here
Transanal Versus Laparoscopic TME: All That Glitters is Not Gold. Montserrat Guraieb-Trueba, George J. Chang. Annals of surgery. Jan 2023 277(1) 8-Jul. doi: 10.1097/SLA.0000000000005655. PMID: 35916131. View here
Author Correction: Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy (Nature, (2022), 606, 7915, (797-803), 10.1038/s41586-022-04833-8). Christopher P. Vellano, Michael G. White, Miles C. Andrews, Manoj Chelvanambi, Russell G. Witt, Joseph R. Daniele, Mark Titus, Jennifer L. McQuade, Fabio Conforti, Elizabeth M. Burton, Matthew J. Lastrapes, Gabriel Ologun, Alexandria P. Cogdill, Golnaz Morad, Peter Prieto, Alexander J. Lazar, Yanshuo Chu, Guangchun Han, M. A.Wadud Khan, Beth Helmink, Michael A. Davies, Rodabe N. Amaria, Jeffrey J. Kovacs, Scott E. Woodman, Sapna Patel, Patrick Hwu, Michael Peoples, Jeffrey E. Lee, Zachary A. Cooper, Haifeng Zhu, Guang Gao, Hiya Banerjee, Mike Lau, Jeffrey E. Gershenwald, Anthony Lucci, Emily Z. Keung, Merrick I. Ross, Laura Pala, Eleonora Pagan, Rossana Lazcano Segura, Qian Liu, Mikayla S. Borthwick, Eric Lau, Melinda S. Yates, Shannon N. Westin, Khalida Wani, Michael T. Tetzlaff, Lauren E. Haydu, Mikhila Mahendra, Xiao Yan Ma, Christopher Logothetis, Zachary Kulstad, Sarah Johnson, Courtney W. Hudgens, Ningping Feng, Lorenzo Federico, Georgina V. Long, P. Andrew Futreal, Swathi Arur, Hussein A. Tawbi, Amy E. Moran, Linghua Wang, Timothy P. Heffernan, Joseph R. Marszalek, Jennifer A. Wargo. Nature. Jan 2023 613(7945) E3. doi: 10.1038/s41586-022-05632-x. PMID: 36627494. View here
Rectal Adenocarcinoma Presenting as a Cervical Mass: A Case Report. Nir Stanietzky, Brian Bednarski, Aaron Shafer, Melissa W. Taggart, Oliver Peacock, Raghunandan Vikram. American Journal of Case Reports. 2023 24() e941884-1-e941884-6. doi: 10.12659/AJCR.941884. PMID: 38011075. View here
Preoperative Treatment of Locally Advanced Rectal Cancer. Deborah Schrag, Qian Shi, Martin R. Weiser, Marc J. Gollub, Leonard B. Saltz, Benjamin L. Musher, Joel Goldberg, Tareq Al Baghdadi, Karyn A. Goodman, Robert R. Mcwilliams, Jeffrey M. Farma, Thomas J. George, Hagen F. Kennecke, Ardaman Shergill, Michael Montemurro, Garth D. Nelson, Brian Colgrove, Vallerie Gordon, Alan P. Venook, Eileen M. O'reilly, Jeffrey A. Meyerhardt, Amylou C. Dueck, Ethan Basch, George J. Chang, Harvey J. Mamon. New England Journal of Medicine. 2023 389(4) 322-334. doi: 10.1056/NEJMoa2303269. PMID: 37272534. View here
Stranger Things: New Roles and Opportunities for Androgen Receptor in Oncology Beyond Prostate Cancer. Javier Leo, Eleonora Dondossola, Kaitlin J. Basham, Nathaniel R. Wilson, Omar Alhalabi, Jianjun Gao, Katherine C. Kurnit, Michael G. White, Jennifer L. McQuade, Shannon N. Westin, Elizabeth A. Wellberg, Daniel E. Frigo. Endocrinology. 2023 164(6) bqad071. doi: 10.1210/endocr/bqad071. PMID: 37154098. View here
Multivisceral resection for colonic splenic flexure malakoplakia: a case report of a minimally invasive approach. Andrés Ramiro Lanza Díaz, Santiago Gallardo Pezet, Osvaldo Soto González, Montserrat Guraieb Trueba, Ivan Azael Martínez Alonso, Mario Alberto L. Ramirez. Annals of Coloproctology. 2023 39(2) 178-182. doi: 10.3393/ac.2021.00178.0025. PMID: 34284559. View here
Colorectal surveillance outcomes from an institutional longitudinal cohort of lynch syndrome carriers. Gabriel del Carmen, Laura Reyes-Uribe, Daniel Goyco, Kyera Evans, Charles M. Bowen, Jennifer L. Kinnison, Valerie O. Sepeda, Diane M. Weber, Julie Moskowitz, Maureen E. Mork, Selvi Thirumurthi, Patrick M. Lynch, Miguel A. Rodriguez-Bigas, Melissa W. Taggart, Y. Nancy You, Eduardo Vilar. Frontiers in Oncology. 2023 13() 1146825. doi: 10.3389/fonc.2023.1146825. PMID: 37168379. View here
HPV-related anal cancer is associated with changes in the anorectal microbiome during cancer development. Jacob H. Elnaggar, Victoria O. Huynh, Daniel Lin, R. Tyler Hillman, Chike O. Abana, Molly B. El Alam, Katarina C. Tomasic, Tatiana V. Karpinets, Ramez Kouzy, Jae L. Phan, Jennifer Wargo, Emma B. Holliday, Prajnan Das, Melissa P. Mezzari, Nadim J. Ajami, Erica J. Lynn, Bruce D. Minsky, Van K. Morris, Andrea Milbourne, Craig A. Messick, Ann H. Klopp, P. Andrew Futreal, Cullen M. Taniguchi, Kathleen M. Schmeler, Lauren E. Colbert. Frontiers in immunology. 2023 14() 1051431. doi: 10.3389/fimmu.2023.1051431. PMID: 37063829. View here