Ovarian cancer metastasis study identifies important protein with potential as diagnostic tool and treatment option
Advanced ovarian cancer most commonly metastasizes to the omentum, a layer of fatty tissue that wraps around and protects internal organs in the abdomen, but the reasons for this have not been well-understood. In a new study, MD Anderson researchers discovered that a protein called omentin, or ITLN1, works to prevent metastasis of the cancer cells, but it is lost as the cancer develops.
Their preclinical findings, published in...
Twelve MD Anderson researchers honored with 2020 AACR Team Science Awards
The American Association for Cancer Research (AACR) is recognizing the founding members of The Cancer Genome Atlas (TCGA) ...
Brain metastases recruit suppressive immune cells via novel pathway to facilitate their growth
MD Anderson researchers have discovered that metastatic cancer cells in the brain upregulate expression of the EZH2 gene to activate a previously...
ASCO: Emerging approaches to improve immunotherapy for cancer treatment
Brian Odle has now overcome four cancer diagnoses in his life, thanks to inheriting a mutation in the TP53 gene. This inherited condition is known as Li-Fraumeni Syndrome and puts carriers at an increased risk of several cancer types.
By summer 2019, Brian had been successfully treated for a large germ cell tumor, melanoma and osteosarcoma. However, that summer he began feeling poorly, and his MD Anderson care team ordered a bone...
ASCO: Emerging targeted therapies show signs of clinical activity across multiple cancer types
Julia Pitts tried all the standard treatment options with her local physicians after she was diagnosed with metastatic uterine cancer in 2015...
Larotrectinib shows marked responses with NTRK gene fusions, limited response in non-fusion mutations
In an analysis of three clinical trials, the targeted therapy larotrectinib resulted in a 79% overall response rate and median overall survival...
Genomic study of brain metastases sheds light on unique features relative to primary tumors
A deep sequencing study of brain metastases from MD Anderson revealed many similarities but also distinct differences relative to the primary...
Acute myeloid leukemia’s minimal residual disease targeted by Moon Shot
In patients with leukemia, complete remission after treatment is currently defined by the absence of cancer cells in a bone marrow biopsy...
Triple-negative breast cancer clinical trial allies with community oncologists
Triple-negative breast cancer (TNBC) is an aggressive disease that makes up roughly 15% to 20% of breast cancer diagnoses. Standard chemotherapy...
Ovarian Cancer Moon Shot works to broaden immunotherapy impact
Immunotherapies have brought the potential for long-term remission and even cures to patients with many cancer types, but the benefits have...