Study #2023-0350
Alliance A091903: A randomized phase II trial of adjuvant Nivolumab with or without Cabozantinib in patients with resected mucosal melanoma
MD Anderson Study Status
Enrolling
Treatment Agent
Cabozantinib S-malate, Nivolumab, Placebo Administration
Description
This phase II trial tests whether nivolumab in combination with cabozantinib works in patients with mucosal melanoma. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It works by blocking the action of an abnormal protein that signals tumor cells to multiply. This helps stop the spread of tumor cells. Giving nivolumab in combination with cabozantinib could prevent cancer from returning.
Resources and Links
Phone Number: 1-877-MDA-6789
Information and next steps
Disease:
Anal Melanoma, Bladder Melanoma, Cervical Melanoma, Esophageal Melanoma, Gallbladder Melanoma, Mucosal Melanoma, Mucosal Melanoma of the Head and Neck, Mucosal Melanoma of the Urinary System, Nasopharyngeal Melanoma, Oral Cavity Mucosal Melanoma, Penile Mucosal Melanoma, Rectal Melanoma, Recurrent Mucosal Melanoma, Sinonasal Mucosal Melanoma, Stage II Vulvar Cancer AJCC v8, Stage III Vulvar Cancer AJCC v8, Stage IV Vulvar Cancer AJCC v8, Urethral Melanoma, Vaginal Melanoma, Vulvar Melanoma
Study phase:
Phase II
Physician name:
Jennifer McQuade
Department:
Melanoma Medical Oncology
For general questions about clinical trials:
1-877-632-6789
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