Study #2018-0381
Phase 2 Study (With Safety Lead In) Of The Safety, Tolerability And Efficacy Of Anti-CTLA4 (Ipilimumab) And Anti-PD-1 (Nivolumab) In Combination With Radiation Therapy To 60 Gy In Low-Intermediate Volume, Local-Regionally Advanced HPV-Positive Oropharynge
MD Anderson Study Status
Not Accepting
Treatment Agent
Ipilimumab, Nivolumab
Description
This phase II trial studies the side effects and best dose of ipilimumab, nivolumab, and radiation therapy and how well they work in treating patients with advanced human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma. Immunotherapy with monoclonal antibodies, such as ipilimumab and nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Giving ipilimumab, nivolumab, and radiation therapy may work better in treating patients with HPV positive oropharyngeal squamous cell carcinoma.
Resources and Links
Phone Number: 1-877-MDA-6789
Information and next steps
Disease:
Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC V8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC V8, Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma, Oropharyngeal Basaloid Carcinoma, Pathologic Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC V8, Pathologic Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC V8, Posterior Tongue Squamous Cell Carcinoma, Soft Palate Squamous Cell Carcinoma, Stage III Oropharyngeal Squamous Cell Carcinoma AJCC V7, Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC V7, Tonsillar Squamous Cell Carcinoma
Study phase:
Phase II
Physician name:
Maura Gillison
Department:
Thoracic/Head & Neck Medical Oncology
For general questions about clinical trials:
1-877-632-6789
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