Study #2016-0108
Phase II Clinical Trial Evaluating Intravenous AZD9150 (antisense STAT3) with MEDI4736 (anti-PD-L1) in Patients with Advanced Pancreatic, Non-small Cell Lung Cancer, and Mismatch Repair Deficient Colorectal Cancer
MD Anderson Study Status
Not Accepting
Treatment Agent
Danvatirsen, Durvalumab
Description
This phase II trial studies how well danvatirsen and durvalumab work in treating patients with pancreatic cancer, non-small cell lung cancer and mismatch repair deficient colorectal cancer that has spread to other places in the body and does not respond to treatment. Danvatirsen may be used to block the production of proteins needed for tumor cell growth. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving danvatirsen and durvalumab may work better at treating pancreatic cancer, non-small cell lung cancer and mismatch repair deficient colorectal cancer.
Resources and Links
Phone Number: 1-877-MDA-6789
Information and next steps
Disease:
Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma, Lung Non-Small Cell Carcinoma, Mismatch Repair Deficiency, Refractory Colorectal Carcinoma, Refractory Lung Carcinoma, Refractory Pancreatic Carcinoma, Stage II Pancreatic Cancer AJCC V8, Stage III Colorectal Cancer AJCC V8, Stage III Lung Cancer AJCC V8, Stage III Pancreatic Cancer AJCC V8, Stage IIIA Colorectal Cancer AJCC V8, Stage IIIA Lung Cancer AJCC V8, Stage IIIB Colorectal Cancer AJCC V8, Stage IIIB Lung Cancer AJCC V8, Stage IIIC Colorectal Cancer AJCC V8, Stage IIIC Lung Cancer AJCC V8, Stage IV Colorectal Cancer AJCC V8, Stage IV Lung Cancer AJCC V8, Stage IV Pancreatic Cancer AJCC V8, Stage IVA Colorectal Cancer AJCC V8, Stage IVA Lung Cancer AJCC V8, Stage IVB Colorectal Cancer AJCC V8, Stage IVB Lung Cancer AJCC V8, Stage IVC Colorectal Cancer AJCC V8
Study phase:
Phase II
Physician name:
David Sanghyun Hong
Department:
Investigational Cancer Therapeutics
For general questions about clinical trials:
1-833-676-1615
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