Lost metabolic fitness of CAR NK cells is key mechanism of tumor resistance
A new study led by researchers at The University of Texas MD Anderson Cancer Center discovered loss of metabolic fitness in chimeric antigen receptor (CAR) natural killer (NK) cells is a critical mechanism of resistance, with infused cells gradually losing the ability to compete with tumor cells for nutrients, leading to tumor relapse.
The study, published today in Science Advances, demonstrates that engineering CAR NK cells to...
