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MOON SHOTS PROGRAM
Chronic lymphocytic leukemia (CLL) develops slowly, creating defective white blood cells that can’t produce antibodies against infection. The average age of patients at diagnosis is 70. As more people age, more will develop CLL.
The Chronic Lymphocytic Leukemia Moon Shot® is revolutionizing the conventional medical research approach to rapidly adapt pre-clinical findings into CLL treatment options. We’re focusing our largest efforts on the approaches that will have near‐term measurable success on the crucial issues facing CLL patients.
Maria Teresa Bertilaccio, Ph.D.
Assistant Professor, Experimental Therapeutics
Varsha Gandhi, Ph.D.
Chair Ad Interim, Experimental Therapeutics and Professor, Leukemia
Nitin Jain, M.D.
Associate Professor, Leukemia
William Wierda, M.D., Ph.D.
Professor, Leukemia
Your gift can help propel new clinical trials aimed at improving
outcomes for leukemia patients who face the current incurability of
their disease.
According to results from a Phase I/IIa trial at MD Anderson, treatment with cord blood-derived chimeric antigen receptor (CAR) natural killer (NK)-cell therapy targeting CD19 resulted in clinical responses in a majority of patients with relapsed or refractory non-Hodgkin’s lymphoma (NHL) and chronic lymphocytic leukemia (CLL), with no major toxicities observed.
Learn moreA combination of ibrutinib and venetoclax was found to provide lasting disease remission in patients with newly diagnosed chronic lymphocytic leukemia (CLL), according to researchers at MD Anderson. Findings from the single-institution Phase II study were published in JAMA Oncology and provide the longest follow-up data on patients treated with this drug regimen.
Treatment advances for CLL, the most common leukemia
Chronic lymphocytic leukemia (CLL), which originates in white blood cells known as lymphocytes, is the most common form of leukemia in adults. Built upon the long-standing expertise of clinicians and researchers at MD Anderson, the CLL Moon Shot® is working toward improved treatments for CLL through new immunotherapy approaches, a better understanding of CLL genetics, and novel targeted therapies.
