Lymphoma & Myeloma Clinical Trials
Last Updated: 05/30/2025
CAR T/Cellular Therapy
Lymphoma CAR T/Cellular Therapy
Previously Untreated
2020-0872 A Pilot "Window-3" Study of Acalabrutinib Plus Rituximab Followed by Brexucabtagene Autoleucel Therapy in Patients With Previously Untreated High-risk Mantle Cell Lymphoma
2022-0463 An Adaptive Phase 3, Randomized, Open-Label, Multicenter Study to Compare the Efficacy and Safety of Axicabtagene Ciloleucel versus Standard of Care Therapy as First-Line Therapy in Subjects with High-Risk Large B-Cell Lymphoma
Previously Treated
2021-0468 Phase I, open label, multicenter, dose escalation study of YTB323 in adult patients with CLL/SLL, DLBCL and ALL
2020-1136 A Phase 1/2 Open-label, Multicenter Study Evaluating the Safety and Efficacy of KITE-363, an Autologous Anti-CD19/CD20 CAR T-cell Therapy, in Subjects With Relapsed and/or Refractory B-cell Lymphoma
2023-0639 Long-term follow-up study for participants previously treated with Ciltacabtagene Autoleucel
2023-0202 A Phase 1 multicenter study evaluating the safety and efficacy of ACE1831, an Allogeneic CD20-Conjugated Gamma Delta T-Cell therapy, In adult subjects with relapsed/refractory CD20-expressing B-Cell malignancies
2020-0660 Expanded access protocol (eap) for patients receiving lisocabtagene maraleucel that is nonconforming for commercial release
Myeloma CAR T/Cell Therapy
Previously Treated
Lymphoma Clinical Trials
Non Hodgkins Lymphoma
Indolent Lymphoma (Follicular, Marginal Zone, Small Lymphocytic Leukemia)
Previously Untreated
2024-0114 A phase 3, multicenter, randomized, open-label trial to evaluate the safety and efficacy of Epcoritamab + Rituximab and Lenalidomide (R^2 ) compared to chemoimmunotherapy in previously untreated follicular lymphoma (EPCORE FL-2).
2024-0385 Randomized Phase III Study of Mosunetuzumab Vs. Rituximab for Low Tumor Burden Follicular Lymphoma
Previously Treated
2024-0243 A phase 2 trial of mosunetuzumab and zanubrutinib for patients with relapsed/refractory marginal zone lymphoma
2023-0610 Phase 1, open-label study of Autologous SIRPa-low Macrophages (sirpant-m) administered by intratumoral injection alone or in combination with focal external-beam radiotherapy in participants with relapsed or refractory Non-Hodgkin's Lymphoma.
2022-0394 A Phase lb, Open-Label, Multicenter Study Evaluating the Safety, Pharmacokinetics, And Efficacy of Mosunetuzumab or Glofitamab In Combination With CC-220 And CC-99282 In Patients With B-Cell Non-Hodgkin Lymphoma
2021-0091 A Multicenter, Phase1, Open-label, Dose-escalation and Expansion Study of TNB-486, a Bispecific Antibody Targeting CD19 in Subjects with Relapsed or Refractory B-cell Non Hodkins Lymphoma
2018-1160 (CC-99282): A Phase I, Multi-Center, Open Label Study to Assess the Safety, Pharmacokinetics, and Preliminary Efficacy of an Orally Available Small Molecule, CC-99282, Alone and in Combination with Rituximab in Subjects with Relapsed or Refractory Non-Hodgkins Lymphoma
2022-0551 A phase 1/2, open-label study of Valemetostat in combination with Rituximab and Lenalidomide in relapsed or refractory Follicular Lymphoma
2023-0335 A phase 3 randomized, open-label, multicenter study of Zanubrutinib (BGB-3111) plus anti-CD20 antibodies versus Lenalidomide Plus Rituximab in patients with Relapsed/Refractory follicular or marginal zone lymphoma
2022-0459 A phase II trial of Mosunetuzumab, Polatuzumab, Tafasitamab, and Lenalidomide in patients with relapsed B-cell NHL
2019-1250 A Phase 2, Open-Label, Single-Arm, Multi Cohort, Multi-Center Trial to Evaluate the Efficacy and Safety of JCAR017 in Adult Subjects with Relapsed or Refractory Indolent B-Cell Non-Hodgkin Lymphoma (NHLl)
2024-0115 A Phase 3, Randomized, Open-Label StudyComparing the Efficacy and Safety of the Combination of Beleodaq-CHOP or Folotyn-COP to the CHOP Regimen Alone in Newly Diagnosed Patients with Peripheral T-Cell Lymphoma
Aggressive Lymphoma (Large B cell Lymphoma, Diffuse Large B cell Lymphoma, Burkitt's Lymphoma)
Newly diagnosed
2024-1146 Ph3 study GOLSEEK-1 in participants with previously untreated high-risk large B-cell Lymphoma
2021-0046 Smart Stop: A Phase II trial of Rituximab,Lenalidomide, Acalabrutinib, Tafasitamab prior to and with standard chemotherapy for patients with newly diagnosed DLBCL
2020-0686 A Phase II Study to Determine the Response Kinetics, Safety and Efficacy of Brentuximab Vedotin and Nivolumab Alone and then Combined with Rituximab, Cyclophosphamide, Doxorubicin and Prednisone for Patients with Untreated Primary Mediastinal Large B-cell Lymphoma
2023-0031 Phase 2 trial of Epcoritamab in combination with Rituximab-mini CVP for older unfit/frail patients or anthracycline-ineligible adult patients with newly diagnosed diffuse large B-cell Lymphoma.
Previously Treated
2024-0431 A randomized, open-label study evaluating the efficacy and safety of cemacabtagene ansegedleucel in participants with minimal residual disease after response to first line therapy for large B-cell lymphoma (ALPHA3)
2023-0673 A phase 2 Study of Axicabtagene Ciloleucel and Glofitamab as second-line therapy for relapsed or refractory, or high-risk untreated patients with large B Cell Lymphoma
2023-0610 Phase 1, open-label study of Autologous SIRPa-low Macrophages (sirpant-m) administered by intratumoral injection alone or in combination with focal external-beam radiotherapy in participants with relapsed or refractory Non-Hodgkin's Lymphoma.
2023-0485 An open-label, multicenter phase 2 study Evaluating the Efficacy and Safety of CRG-022, a CD22-directed Autologous Chimeric Antigen Receptor (CAR) T-cell Therapy in Participants with Relapsed/Refractory Large B-Cell Lymphoma after CD19-directed CAR T-cell Therapy
2021-1169 REAL-MIND: Prospective multicenter observational study of patients with relapsed or refractory diffuse large B-cell lymphoma starting second- or third-line therapy and not receiving autologous stem cell transplant
2022-0147 A Phase II Study of Loncastuximab Tesirine as Consolidation Strategy in Patients with Large B-cell Lymphoma who Achieve Partial Remission After CAR T-cell Therapy
PA15-0957 DNA Sequencing-Based Monitoring of Minimal Residual Disease to Predict Clinical Relapse in Aggressive B-cell Non-Hodgkin Lymphomas
2018-1160 (CC-99282): A Phase I, Multi-Center, Open Label Study to Assess the Safety, Pharmacokinetics, and Preliminary Efficacy of an Orally Available Small Molecule, CC-99282, Alone and in Combination with Rituximab in Subjects with Relapsed or Refractory Non-Hodgkins Lymphoma
Mantle Cell Lymphoma
Newly Diagnosed
2023-0413 Phase II study of Pirtobrutinib, rituximab (PR) in previously untreated low and intermediate risk MCL (mantle cell lymphoma) patients
2024-0220 GATE1: A multicenter phase II study of pirtobrutinib, rituximab and venetoclax combination therapy for patients with previously untreated mantle cell lymphoma
Previously Treated
2023-0695 Tafasitamab, Lenalidomide and Venetoclax combination therapy for relapsed or refractory Mantle Cell Lymphoma (V-MIND)
2021-1108 Phase II Study of Pirtobrutinib With Venetoclax In Relapsed-Refractory MCL (Mantle Cell Lymphoma) Patients
2025-0045 A phase 3 randomized double-blind multicenter study of sonrotoclax plus zanubrutinib versus placebo plus zanubrutinib in patients with relapsed/refractory mantle cell lymphoma
2024-1726 Phase 1 trial of BTM-3566 in relapsed/refractory mature B Cell Lymphomas.
Hodgkin Lymphoma
Newly Diagnosed
2022-1065 NCI10590: NORM: nodular lymphocyte-predominant Hodgkin lymphoma patients treated in a randomized phase 2 trial with either Rituximab or Mosunetuzumab
Previously Treated
2024-0430 A phase 1 first in human study of ARV-393 in adult participants with advanced Non-Hodgkin's Lymphoma
2022-1065 NCI10590: NORM: nodular lymphocyte-predominant Hodgkin lymphoma patients treated in a randomized phase 2 trial with either Rituximab or Mosunetuzumab
2022-1065 NCI10590: NORM: nodular lymphocyte-predominant Hodgkin lymphoma patients treated in a randomized phase 2 trial with either Rituximab or Mosunetuzumab
2023-0613 A phase 1/2a, open-label, dose escalation trial of GEN3017 with expansion cohorts in relapsed or refractory CD30+ classical Hodgkin lymphoma and CD30+ non-Hodgkin lymphoma
2021-1033 An open-label, multi-center, non-randomized phase I dose escalation study to investigate the safety, tolerability, pharmacokinetics, and preliminary efficacy of ONO-4685 given as monotherapy in patients with relapsed or refractory T-cell Lymphoma
T-Cell Lymphoma
Newly Diagnosed
2024-0115 A phase 3, randomized, open-label study comparing the efficacy and safety of the combination of Beleodaq-CHOP or Folotyn-COP to the CHOP regimen alone in newly diagnosed patients with peripheral T cell lymphoma.
Previously Treated
2024-1024 A Phase II multicenter open-label trial of tagraxofusp (Tag) in combination with venetoclax and azacitidine (Ven/Aza) in adults with previously untreated CD123+ acute myeloid leukemia (AML) who are ineligible for intensive chemotherapy
2023-0962 A phase 3, randomized, open-label study to investigate the efficacy and safety of ITK inhibitor Soquelitinib versus physician's choice standard of care treatment (Selected Single Agent) in participants with Relapsed/Refractory peripheral T-cell Lymphoma not otherwise specified, Follicular Helper T-cell Lymphomas, or Systemic Anaplastic Large-cell Lymphoma
2017-0927 A Phase 2 Study of Brentuximab Vedotin Plus Cyclophosphamide, Doxorubicin, Etoposide, and Prednisone (CHEP-BV) Followed by BV Consolidation in Patients with CD30-Positive Peripheral T-cell Lymphomas
2018-1064 (TTI-622): A Phase 1a/1b Dose Escalation and Expansion Trial of TTI-622 in Patients with Advance Relapsed or Refractory Lymphoma or Myeloma
2021-1033 An open-label, multi-center, non-randomized phase I dose escalation study to investigate the safety, tolerability, pharmacokinetics, and preliminary efficacy of ONO-4685 given as monotherapy in patients with relapsed or refractory T-cell Lymphoma
Multiple Myeloma Clinical Trials
Newly Diagnosed
2024-0003 Phase 1, First-in-Human, Dose Escalation Study of JNJ-79635322, a Trispecific Antibody, in Participants with Relapsed or Refractory Multiple Myeloma or Previously Treated AL Amyloidosis
2023-0617 SWOG S2209: A phase III randomized trial for newly diagnosed Multiple Myeloma (NDMM) patients considered frail or in a subset of "intermediate fit" comparing upfront three-drug induction regimens followed by double- or single-agent maintenance.
2021-0191 (DETER-SMM) EAA173: Daratumumab to Enhance Therapeutic Effectiveness of Revlimid in Smoldering Myeloma (DETER-SMM)
2020-0431 A Phase 1 with Extension Cohort, Single Arm, Single Center, Open Label Trial of Belantamab Mafodotin for the Treatment of High-Risk Smoldering Multiple Myeloma
2023-0363 Phase 1/2 Study of Linvoseltamab (Anti-BCMA X Anti-CD3 Bispecific Antibody) in previously untreated patients with symptomatic multiple Myeloma (Linker-MM4 Study)
PA19-0436 Molecular Monitoring of Myeloma Response and Resistance mechanisms: NDMM - tx naïve; planning on frontline therapy that contains PI and/or IMiD
2023-0322 A Phase 3, Two-stage, Randomized, Multi-center, Controlled, Open-label Study Comparing
Previously Treated
2024-1162 A phase 1b/2 study of GC012F (AZD0120), a chimeric antigen receptor T-cell (CAR T) therapy targeting CD19 and B-cell maturation antigen (BCMA) in subjects with relapsed/refractory multiple myeloma
2023-0502 A phase 1, multicenter, open-label study to evaluate the safety and preliminary efficacy of BMS-986393 in novel combinations in participants with relapsed and/or refractory multiple myeloma and determine the recommended dose for each add-on investigational component
2023-0719 A phase 3, two-stage, randomized, multicenter, open-label study comparing Mezigdomide(CC-92480), Bortezomib and Dexamethasone (MeziVd)versus Pomalidomide,Bortezomib and Dexamethasone (PVD) in subjects with Relapsed or Refractory Multiple myeloma (RRMM): successor-1
2023-0527 Phase I/II open label study of Belumosudil Mesylate alone, and in combination with Dexamethasone, in patients with relapsed/refractory multiple myeloma
2024-1148 A Phase 3, Randomized, Open-Label Study to Compare the Efficacy and Safety of Anitocabtagene Autoleucel Versus Standard of Care Therapy in Participants With Relapsed/Refractory Multiple Myeloma
2021-0185 A Phase 1/2a, First-in-human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of HDP -101 in Patients with Plasma Cell Disorders Including Multiple Myeloma
2023-0420 Phase 1/2 study of IDP 023 as a single agent and in combination with antibody therapies in patients with advanced Hematologic cancers.
2023-1048 A Phase 2, Open-Label, Multicenter Study of BMS-986393, a GPRC5D-directed CAR T Cell Therapy in Adult Participants with Relapsed or Refractory Multiple Myeloma (QUINTESSENTIAL)
2023-0171 Phase I/II Trial of Cord Blood-Derived NK Cells Genetically Engineered with NY-ESO-1 TCR/IL-15 Cell Receptor for Relapsed/Refractory Multiple Myeloma
2024-0003 Phase 1, First-in-Human, Dose Escalation Study of JNJ-79635322, a Trispecific Antibody, in Participants with Relapsed or Refractory Multiple Myeloma or Previously Treated AL Amyloidosis
2024-1162 A Ph 1b/2 study of GC012F in subjects with relapsed/refractory multiple myeloma
Waldenstrom’s Previously Treated:
2023-0106 First-in-Human Study to Evaluate the Safety, Pharmacokinetics, and Preliminary Efficacy of the BTK Degrader, ABBV-101, in Participants with B-cell Malignancies
AL Amyloid:
2024-1019 SWOG: Study S2213 a phase III, randomized study of Daratumumab, Cyclophosphamide, Bortezomib and Dexamethasone (DaraVCD)
Induction followed by Autologous Stem Cell Transplant or Dara-VCD consolidation and Daratumumab maintenance in patients with newly diagnosed AL Amyloidosis
2024-0160 A phase 1/2 study of linvoseltamab in patients with relapsed or refractory systemic light chain amyloidosis
Untreated SGUS/SMM:
PA15-0575: Observational prospective research study in monoclonal Gammopathies leadINg to myeloma (ORIGIN study)
2016-0172: Quality of Life in Patients with Asymptomatic Monoclonal Gammopathies (MGUS/SMM)
2021-0191: EAA173: Daratumumab to Enhance Therapeutic Effectiveness of Revlimid in Smoldering Myeloma (DETER-SMM)
2020-0431: A Phase 1 with Extension Cohort, Single Arm, Single Center, Open Label Trial of Belantamab Mafodotin for the Treatment of High-Risk Smoldering Multiple Myeloma (BELLA)
Laboratory Studies:
PA18-1073: Pilot study of the validation of as single cell proteopenomic assay in multiple myeloma and its precursor stages (PCL / LPL)
PA19-0436- Molecular Monitoring of Myeloma Response and Resistance mechanisms: NDMM - tx naïve; planning on frontline therapy that contains PI and/or IMiD
2021-0440: A Collection of Blood and Tissue Samples from Patients with Amyloidosis and/or Monoclonal Gammopathies (including Lymphoplasmacytic Lymphoma) and Normal Donors
Other Clinical Trials
2024-0391 Project DANCES (diversity in Aya caNCEr survivors)
2024-0453 An open-label, dose escalation and dose expansion trial evaluating the safety, pharmacokinetics, pharmacodynamics, and clinical activity of orally administered CA-4948 in patients with relapsed or refractory primary central nervous system lymphoma
2024-0160 A phase 1/2 study of linvoseltamab in patients with relapsed or refractory systemic light chain amyloidosis
2023-0942 Study of AZD3470 in participants with relapsed/refractory Hematologic Malignancies.
2023-0864 A pilot study of Emapalumab for the treatment of CAR T-Cell therapy-associated prolonged cytopenia
2023-0738 An open-label phase 1 study to evaluate the safety of SGN-35T in adults with advanced malignancies
2023-0581 A randomized trial of fecal microbiota transplantation for remedying antibiotics-induced microbiota dysbiosis in lymphoma patients receiving Axicabtagene Ciloleucel therapy
2022-0358 Real-World Outcomes in Patients with Relapsed or Refractory (R/R) Aggressive B-cell Non-Hodgkin Lymphoma (aNHL)
2021-0393 Analysis of apheresis and infusion product retains from lymphoma patients treated with standard of care axicabtagene ciloleucel
2005-0656 A Collection of Blood and Tissue Samples from Patients with Lymphoma and/or Myeloma and Normal Donors
2022-0784 Myeloma Genetics and Epidemiology - Genetica y Epidemiologia de Mieloma (GEM Study)
2022-0533 Disparities among Childhood and Adolescent/Young Adult (AYA) Cancer Populations
PA15-0575 Observational prospective research study in monoclonal Gammopathies leadINg to myeloma (ORIGIN study)
2021-1088 A Multicenter, Open-label Feasibility Study of Daratumumab with Dose-Adjusted EPOCH in Newly Diagnosed Plasmablastic Lymphoma with or without HIV
2021-0758 Long-term Follow-up Study for Participants of Kite-Sponsored Interventional Studies Treated With Gene-Modified Cells
2022-0396 Feasibility of Combined Genomics/Transcriptomics for Patients with Lymphoma
2020-0238 A Phase 1, Open-Label, Multicenter, Dose Escalation and Cohort Expansion Study of the Safety and Efficacy of Anti-CD70 Allogeneic CRISPR-Cas9-Engineered T Cells (CTX130) in Adult Subjects With R/R T or B Cell Malignancies
2021-0392 Collection of blood samples from normal donors
2021-0440 A Collection of Blood and Tissue Samples from Patients with Amyloidosis and/or Monoclonal Gammopathies (including Lymphoplasmacytic Lymphoma) and Normal Donors
2021-0816 A Study to Evaluate Long-Term Safety of CAR-T Cell Therapy in Patients with Hematologic Malignancies
2022-0052 A Prospective Study Of Conventional Bone Marrow Biopsies And Bone Marrow Biopsies Performed Through An Indwelling Bone Marrow Port, Using A Modified PROMIS Pain Intensity Scale For Pain Assessment
2022-0193 Outcomes of Cutaneous T-Cell Lymphoma Patients on Mogamulizumab
PA14-0094 The Lymphoma Epidemiology of Outcomes (LEO) Cohort Study Protocol
2021-0049 HSP70 as a target for New drugs in Multiple Myeloma and Lymphoma
2023-0218 Pilot study to assess the feasibility, cost-effectiveness, and patient-reported outcomes of outpatient CAR T-cell administration for patients with Multiple Myeloma
2023-0253 Intermediate-size population expanded access program (EAP) for ciltacabtagene autoleucel (cilta-cel) out-of-specification (OOS) in patients with multiple myeloma
2022-0492 PET adapted Brentuximab Vedotin and Pembrolizumab in combination with Doxorubicin and Dacarbazine in Classic Hodgkin Lymphoma
2022-0603 Feasibility and clinical utility of cell-free DNA (cfDNA) in identifying actionable alterations and minimal residual disease for lymphoma patients across community centers in Texas.
2023-0329 An open-label phase II study to investigate the efficacy, safety, and pharmacokinetics of tirabrutinib in patients with Primary Central Nervous System Lymphoma (PCNSL)
2022-0918 Expanded access study for the treatment of patients with commercially out-of-specification Axicabtagene Ciloleucel
2023-0420 Phase 1/2 study of IDP 023 as a single agent and in combination with antibody therapies in patients with advanced Hematologic cancers.
2020-0797 Mechanisms of Late-effects in Childhood and AYA Cancer Survivors